The drawing guide is well done and easy to follow the progression of the drawing. What I like about this step by step drawing book, and what allow it to stand out a bit from the mass, was that it give little stats (speed, strength, etc.) of those little creatures that you learn to draw so kids can create game with them and their imagination, a bit like Pokémon’s, or so many other creatures based like game. Tips for depicting true-to-life anatomy, poses and expressions Step-by-step demonstrations of 27 baby fantasy creatures Even beginners can achieve happy results quickly, without risk to life or limb.Ĭomplete with fascinating insights on habits, habitats and favorite pastimes, Draw Baby Beasties provides groundbreaking, possibly life-saving instruction for artists who dare take on these awesome and adorable adolescents.Įverything you need to draw legendary little ones! Use the easy-to-follow drawing instructions to start assembling simple shapes, then add shading, texture and color to capture magical unicorn foals, flaming phoenix chicks, gruesome gargoyle pups and other fantastical youth of land, sky and sea. Draw Baby Beasties offers a rare, intimate and danger-free view into the formative years of dragons, trolls, harpies and other fantastical creatures. Here at long last is a more practical, less perilous alternative. Many have met ugly ends whiles scaling cliffs for a glimpse of griffon hatchlings, venturing into dark forests in pursuit of moody little Minotaurs or voyaging to sea where newborn krakens toss boats like bath toys. Here at long last is A life-and-limb-saving guide for artists!įor centuries, brave artists have sought the elusive offspring of legend's most infamous beasts. A life-and-limb-saving guide for artists! For centuries, brave artists have sought the elusive offspring of legend's most infamous beasts.
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Open the memory card and format it or get a new one. The solution to this problem is at your fingertips. It is often seen that the display starts blinking. Keep the marker to the side of plus sign if the picture does not get the lighting so that the picture will be much bright. There is a marker in the scale that indicates the correct exposure position. Look at your camera exposure scale, there is the plus on one side and minus on the other side. This is not a fault of the camera but rather it is the setting problem. It is hard to find anyone who is with wild photography but had not this problem. #3 Troubleshoot Regarding the Lighting in the Photos
With a growing open access offering, Wiley is committed to the widest possible dissemination of and access to the content we publish and supports all sustainable models of access. Wiley has partnerships with many of the world’s leading societies and publishes over 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols in STMS subjects. Wiley has published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising professional books, subscription products, certification and training services and online applications and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners. Wiley is a global provider of content and content-enabled workflow solutions in areas of scientific, technical, medical, and scholarly research professional development and education. Forty-eight of our sampled species (nearly one-third) are endemic to South America. Distributional ranges for each of the terminal taxa show that most species (75%) are restricted to only one of six major biogeographical regions. Most taxa have leaves that are more than once-pinnate, and only a few of these (in the formosum and pedatum clades) exhibit the distinct pseudopedate form. Although a rare occurrence in Adiantum, simple leaves occur in three distinct clades (davidii, philippense, peruvianum). A single unique synapomorphy-leaves once-pinnate, usually with prolonged rooting tips-defines the philippense clade. Our maximum likelihood-based ancestral character state reconstructions of leaf blade architecture reveal remarkable convergent evolution across multiple clades for nearly all leaf forms. Although some of these unite to form larger, well-supported lineages, the backbone of our phylogeny has several short branches and generally weak support, making it difficult to accurately assess deep relationships. All sampled taxa can be unequivocally assigned to one of nine robustly supported clades. We build upon previous datasets, providing new data from four plastid markers (rbcL, atpA, rpoA, chlN) for 146 taxa. Here, we present one of the most comprehensive phylogenies for any large (200+ spp.) monophyletic, subcosmopolitan genus of ferns to date. The over 200 species of Adiantum span six continents and are nearly all terrestrial. Despite encompassing an astonishing range of leaf complexity, all species of Adiantum share a unique character state not observed in other ferns: sporangia borne directly on the reflexed leaf margin or "false indusium" (pseudoindusium). Adiantum is among the most distinctive and easily recognized leptosporangiate fern genera. Interestingly, not all 10 genes are expressed simultaneously during latency in all cases. BamHI rightward-transcript RNAs are present in all latency types but are not essential for transformation, and their role remains to be fully elucidated ( 70). EBV-encoded RNAs (EBERs) are nontranslated viral RNAs of unknown function that might be involved in preventing the programmed cell death of infected cells ( 35). LMP1 is critically involved in the effective immortalization and proliferation of B cells that are latently infected by EBV, whereas LMP2 (a and b) proteins serve to block reactivation from latency and increase B-cell survival ( 33, 37, 41). The EBNA leader protein (EBNA-LP) stimulates EBNA2 transcriptional activation ( 27). The EBNA3 family of proteins (3A, 3B, and 3C) encode transcription factors that upregulate viral and cellular genes and play a role in the transformation of human primary B cells ( 7, 70). EBNA2 has multiple functions, including the regulation of expression of latent membrane proteins 1 and 2 (LMP1 and -2), which in turn contribute to the growth and transformation of B cells ( 7). EBV nuclear antigen 1 (EBNA1) is required for replication and for maintenance of the viral genome ( 70). The 10 genes that are generally expressed during latency encode six nuclear proteins, two types of nontranslated RNA, and two membrane proteins. The highly restricted expression of the vast majority of its genes enables EBV to avoid immune detection by cytotoxic T lymphocytes (CTLs) ( 7). In contrast, >100 genes are expressed during lytic replication ( 7). After infection, EBV is maintained in a latent form in which only a few genes are expressed. Once a person is exposed to the virus, EBV persists in vivo within infected B cells for the entire life span of the individual. Although in immunocompetent hosts infection is generally subclinical ( 14), infection in immunodeficient patients can produce significant morbidity and/or mortality ( 40). EBV represents an important health concern since 90% of the world's population is infected ( 14, 55, 70). These data demonstrate that NOD/SCID mice that are reconstituted with human CD34 + cells are susceptible to infection by EBV and accurately recapitulate important aspects of EBV pathogenesis.Įpstein-Barr virus (EBV) is a human gammaherpesvirus that predominantly infects B cells and epithelial cells ( 17, 18, 45, 56). Finally, we also demonstrate that infection with an enhanced green fluorescent protein (EGFP)-tagged virus can be monitored by the detection of infected EGFP + cells and EGFP + tumors. EBV + lymphoblastoid cell lines expressing human CD45, CD19, CD21, CD23, CD5, and CD30 were readily established from the bone marrow and spleens of infected animals. In addition, tumor cells expressed EBNA1, LMP1, and LMP2a mRNAs, which is consistent with a type II latency program. Their characterization is consistent with that of large cell immunoblastic lymphoma. These tumors stained positive for human CD79a, CD20, CD30, and EBV-encoded RNAs and were light chain restricted. Infected mice presented large visible tumors in multiple organs, most prominently in the spleen. All infected mice lost weight and showed decreased activity levels. High levels of viral DNA were detected in the peripheral blood of all infected mice. We therefore infected reconstituted mice with EBV. NOD/SCID mice engrafted with human CD34 + cells and reconstituted mainly with human B lymphocytes may serve as a useful xenograft model to study EBV infection and pathogenesis. Currently there is no in vivo model that can adequately recapitulate EBV infection and its association with B-cell lymphomas. Impaired T-cell immunity allows the outgrowth of transformed cells with the subsequent production of predominantly B-cell lymphomas. Epstein-Barr virus (EBV)-induced lymphoproliferative disease is an important complication in the context of immune deficiency. Innovation and creativity, after all, is a byproduct of associational thinking - connecting dots between disparate bodies of knowledge, and as Steve Jobs noted in his Stanford commencement speech, “you can’t connect the dots looking forward, you can only connect them looking backward”. REM sleep connects those facts and skills with each other, helping us to develop a more accurate model of how the world works and become more innovative and creative. NREM supports the storage and strengthening of new facts and skills. Two Types of SleepĢ - REM (rapid eye movement) aka ‘dream sleep’ If so, you’re probably not getting enough sleep. How Do I Know If I’m Not Getting Enough Sleep?ġ - Can you fall back asleep at 10 am or 11 am after waking up earlier that day?Ģ - Can you function without caffeine before noon?ģ - Would you sleep right on through your alarm clock if it failed to turn on? If you get 7 hours of sleep for an entire week, the effect on your body and brain is the equivalent of pulling an all nighter. If you’re an entrepreneur or executive trying to battle the afternoon crash by reaching for a cup of coffee, Walker warns us that caffeine has an average half-life of five to seven hours which means if you have a cup of coffee at 3 pm, you’ll still have 50% of that caffeine in your system circa 8 pm to 10 pm, so that difficulty getting a good night’s rest might have a lot to do with your mid-afternoon coffee. The same goes for the old maxim, ‘live each day like it’s your last’ - well, I don’t know about you but if I lived each day like it was my last, it would very quickly be my actual last day. “Routinely sleeping less than six or seven hours a night demolishes your immune system and more than doubles your risk of cancer.” The shorter your sleep the shorter your life-span.įor many years, I pointed to the Bon Jovi song, “Sleep When I Am Dead” as an anthem of sorts, but if you adopt this mindset, Walker warns, you will be dead sooner and the quality of that shorter life will be poorer. I couldn’t fathom how my fellow revelers would sleep right on through to the mid-afternoon.īut the science suggests that routinely sleeping less than six or seven hours a night demolishes your immune system and more than doubles your risk of cancer.Īnd the thing about thinking six hours is enough is you don’t know you’re sleep deprived when you’re sleep deprived. During my twenties and early thirties, when I was more inclined to head out for a big night (I’m now 35 and such nights are now a rarity), I’d think nothing of waking up at 9am on a Saturday morning after having gone to bed at 5am, and venture out for a 10km run, thinking I was invincible and that it was the best way to recover and enjoy the day. I’d judge people who slept until 7 am and write them off as lazy and undisciplined. Utterances like “I can perform well on six hours a night”, and “eight hours is a pipe-dream” are common.Īnd I get it, I said the same thing for almost ten years, willing myself out of bed at 5 am for an early-morning workout, after having slept somewhere between six and seven hours. Sadly, two-thirds of adults throughout all developed nations fail to obtain the recommended eight hours of nightly sleep (which means that there is a 67% chance that you are one of them). So basically, all the important stuff your brain does. Sleeping enriches a diversity of functions related to learning, memory, creativity, decision making, and emotional regulation. Why We SleepĪccording to Matt Walker, professor of neuroscience and psychology at the University of California and author of Why We Sleep: The New Science of Sleep and Dreams, there are numerous reasons why people need to be getting eight hours of sleep a night, and several that stand out as being of utmost importance to entrepreneurs and leaders of teams. Far from the rhetoric of Jocko Willink, a wealth of sleep research provides damning evidence and an overwhelming body of knowledge to suggest that “if you don’t snooze, you lose.” “If you don’t snooze, you lose”. In fact, it can do us a massive disservice insofar as the quality of all of our waking hours is concerned. It’s a case of being ‘up before the enemy’ we’re told.īut being up earlier and having more waking hours in the day does not mean that we have more quality hours. Listen to the likes of leadership coach and retired Navy SEAL, Jocko Willink, and you will be up at the crack of 4:34am, you’ll proceed to splash some cold water on your face and “get after it”, despite every fiber in your body, more likely than not, willing you to go back to sleep. Mod of the Week: Haknslash Essentials for Torchlight II PC Gamer. Every week I spot some new mod content for Torchlight II - a new character class, a new pet, some small but interesting tweaks to the UI or gameplay or loot - but rarely something meaty enough to devote an entire column to. This is not one, but a whole pack of mods! Torchlight II Essentials in Steam Workshop or Haknslash Essentials. Torchlight II GAME MOD Community Class Modpack v 5 1 download. Mod of the Week: Haknslash Essentials, for Torchlight II. It adds a huge amount of new content – classes, monsters and even entire cities! In addition, a new crafting system (Soulcrafting) will appear in the game, as well as Endgame Dungeons, which are distinguished by their complexity. This quick tutorial should help anyone who wants to install a. This is one of the most famous and popular mods for Torchlight 2. Here you can find mods that allow nearly unlimited customization of Torchlight II.
Or equivalently the ratio of luminous intensity I v in lumens/sr (or candelas) to radiant intensity I e in watts/sr. Where the definition is the ratio of luminous (or visible) flux Φ v in lumens to radiant flux Φ e in watts, The relevant conversion factor is called the luminous efficacy K: However for LEDs with a relatively narrow band of emission wavelength, the conversionįrom photometric units (millicandelas) to radiant units (mW/sr) is relatively easy as described below. Involving weighing the human eye response with the actual spectral intensity output of the source. Of an ideal black-body radiator at a specific temperature weighted with the response of the human eye, conversion of an arbitrary optical source from luminous to radiant units requires a calculation Since photometric units are based on a standard mA/mW) so it is convenient to understand how to convert LED intensity specifications between systems. However, photodiode sensitivity is often specified in terms of red, green, white) use the luminous (photometric) units while infrared LEDs use radiant units. Usually LEDs emitting in the visible (e.g. However usually places more radiant intensity into a narrower radiation pattern. The design of real LEDs (chip design and packaging reflectors etc.) Was a planar Lambertian emitter (perfectly diffuse source), the half-intensity angle would be 60 degrees (Lambert's cosine law). The bright center spot is the main radiation field with an intensity half-width of about 15 degrees. A typical radiation fieldįrom a high-radiance red LED is shown to the right. Some LED specification sheets provide a plot showing how the radiation intensity pattern depends on direction angle θ. The steradian (sr) is the unit of solid-angle measurement. 20 mA) and at the peak of the forward emission radiation pattern. (mcd = millicandelas = millilumens per steradian = mlm/sr) at a typical forward current (e.g. Light emitting diodes (LED) have output intensities that are specified in two types of units: radiant intensity (mW/sr = milliWatts per steradian) and luminous intensity (photometric units)
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